
Cellular Neuroscience Imaging Laboratory
Catherine Best-Popescu
University of Illinois Urbana Champaign, at Beckman Institute for Advanced Science and Technology
"We cannot expect in the immediate future that all women who seek it will achieve full equality of opportunity. But if women are to start moving towards that goal, we must believe in ourselves or no one else will believe in us; we must match our aspirations with the competence, courage and determination to succeed.”
Rosalyn Yalow: Medical Physicist, awarded the Nobel prize in 1977
Journal Publications
2021
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Ma Y, Lee Y, Best-Popescu C, Gao L. High-speed compressed-sensing fluorescence lifetime imaging microscopy of live cells. Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2004176118. doi: 10.1073/pnas.2004176118. PMID: 33431663; PMCID: PMC7826382.
2020
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King WP, Amos J, Azer M, Baker D, Bashir R, Best C, Bethke E, Boppart SA, Bralts E, Corey RM, Dietkus R, Durack G, Elbel S, Elliott G, Fava J, Goldenfeld N, Goldstein MH, Hayes C, Herndon N, Jamison S, Johnson B, Johnson H, Johnson M, Kolaczynski J, Lee T, Maslov S, McGregor DJ, Milner D, Moller R, Mosley J, Musser A, Newberger M, Null D, O'Bryan L, Oelze M, O'Leary J, Pagano A, Philpott M, Pianfetti B, Pille A, Pizzuto L, Ricconi B, Rubessa M, Rylowicz S, Shipley C, Singer AC, Stewart B, Switzky R, Tawfick S, Wheeler M, White K, Widloski EM, Wood E, Wood C, Wooldridge AR. Emergency ventilator for COVID-19. PLoS One. 2020 Dec 30;15(12):e0244963. doi: 10.1371/journal.pone.0244963. PMID: 33378363; PMCID: PMC7773325.
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Goswami, N., He, Y. R., Deng, Y-H., Oh, C., Sobh, N., Valera, E., Bashir, R., Ismail, N., Kong, H. J., Nguyen, T. H., Best-Popescu, C., & Popescu, G. (2020). Rapid SARS-CoV-2 Detection and Classification Using Phase Imaging with Computational Specificity. (bioRxiv). Cold Spring Harbor Laboratory Press. https://doi.org/10.1101/2020.12.14.422601
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32. Fanous M, Caputo MP, Lee YJ, Rund LA, Best-Popescu C, Kandel ME, Johnson RW, Das T, Kuchan MJ, Popescu G. Quantifying myelin content in brain tissue using color Spatial Light Interference Microscopy (cSLIM). PLoS One. 2020 Nov 19;15(11):e0241084. doi: 10.1371/journal.pone.0241084. PMID: 33211727; PMCID: PMC7676665.
2019
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M. Kandel, C. Hu, G. Kouzehgarani, E. Min, K. Sullivan, H. Kong, J. Li, D. Robson, M. Gillette, C. Best-Popescu, and G. Popescu, Epi-illumination gradient light interference microscopy for imaging opaque structures, Nature Communications, October 16, 2019.
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R. W. Motl, G.M. Niemiro, M.D. Lisio, S. Suommer, B.J. Riskin and C.A. Best-Popescu Hu, G. Kouzehgarani, E. Min, K. Sullivan, H. Kong, J. Li, D. Robson, M. Gillette, C.A. Best-Popescu, Ultraviolet B Phototherapy Intervention in Patients with Multiple Sclerosis: A Prospective, Randomized Pilot Trial. Journal of Neurological Research and Therapy, 3 (1), (2019). DOI:
10.14302/issn.2470-5020.jnrt-19-2797
2018
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Majeed H, L Ma, Lee YJ, Kandel K, Min E, Jung W, Best-Popescu CA, and G Popescu. Magnified Image Spatial Spectrum (MISS) microscopy for nanometer and millisecond scale label-free imaging. Vol. 26, No. 5 | 5 Mar 2018 | OPTICS EXPRESS 5423
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M.kandel, M. Fanous, C. Best-Popescu, G. Popescu, Real-time halo correction in phase contrast imaging, Biomed. Opt. Express 9, 623-635 (2018).
2016-2017
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Lee Y, Cintora P, Arikkath J, Olaoluwa A, Kandel M, Popescu G and C.A. Best-Popescu. Quantitative assessment of neural outgrowth using spatial light interference microscopy. J. Biomed. Opt. 22 (6) (2017) doi:10.1117/1.
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P. Cintora, Y.J. Lee, G. Popescu and C.A. Best-Popescu. Cell density modulates intracellular mass transport in neural networks Cytometry: Part A, 91(5): 503-509 (2017)
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E. Min, S. Ban, Y. Wang, S. Bae, G. Popescu, C.A. Best-Popescu, and W. Jung. Measurement of multispectral scattering properties in mouse brain tissue, Biomed. Opt. Express 8, 1763-1770 (2017)
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T. H. Nguyen, M. Kandel, H. M. Shakir, C.A Best-Popescu, M. N. Do, and G. Popescu, Halo-free Phase Contrast Microscopy, Scientific Reports (2017)
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M. Landel, H. Shakir, C.A. Best-Popescu, and G. Popescu, Three-Dimensional Intracellular Transport in Neuron Bodies and Neurites Investigated by Label-Free Dispersion-Relation Phase Spectroscopy, Cytometry: Part A (2017)
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E. Min, M.E. Kandel, JK CheMyong, G. Popescu, W. Jung. And C.A. Best-Popescu. Label-free, multi-scale imaging of ex-vivo mouse brain using spatial light interference microscopy, Scientific Reports, 6: (2016)
2010-2015
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Lee S, Park H, Best-Popescu CA, Jang S, Park Y. The Effects of Ethanol on the Morphological and Biochemical Properties of Individual Human Red Blood Cells PLoS ONE 10 (12): e0145327 (2015). PMCID:
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Wang H, Wang B, Kieran N, Jackson K, Spitler K, Sharrock MF, Miller C, Best C, Llano D & D Rose. Brain temperature and its fundamental properties: a review for clinical neuroscientists, Frontiers in Neuroscience, 8:307
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H.V. Pham, B. Bhaduri, K. Tangella, C.A. Best-Popescu and G. Popescu, Real time blood testing using quantitative phase imaging, PloS ONE, 8(2):e55676 (2013).
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Y.K. Park, C.A. Best-Popescu, T.Kuriabova, M.L. Henle, M.S. Feld, A.J. Levine and G. Popescu, Measurement of nonlinear elasticity of red blood cells, Phys. Rev. E, 83 (2011).
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Y. K. Park, C. A. Best-Popescu, R. R. Dasari, and G. Popescu, Light scattering of human red blood cells during metabolic remodeling of the membrane, Biomed Opt 16 (2011).
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Y. K. Park, C. A. Best-Popescu, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine and G. Popescu, Measurement of red blood cell mechanics during morphological changes, Proc. Nat. Acad. Sci., (2010).
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Y. K. Park, C. A. Best-Popescu, T. Auth, N. Gov, S. A. Safran, G. Popescu, S. Suresh and M. S. Feld.Metabolic remodeling of the human red blood cell membrane, Proc. Nat. Acad. Sci., 107, 1289 (2010). PMCID:
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G. Popescu, Y. Park, N. Lue, C.A Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld and K. Badizadegan, Optical imaging of cell mass and growth dynamics, Am J Physiol Cell Physiol, 295, C538-44 (2008). PMCID:
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M Abkarian, M Faivre, R Horton, K Smistrup, CA Best-Popescu, and HA Stone, Cellular-scale hydrodynamics, Biomed Mater., 3, 034011 (2008)
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D Mischoulon, C A Best-Popescu, M Laposata, W Merens, JL Murakami, SL Wu, GI Papakostas, CM Dording, SB Sonawalla, AA Nierenberg, JE Alpert, and M Fava. A double-blind dose-finding pilot study of docosahexaenoic acid (DHA) for major depressive disorder, Eur Neuropsychopharmacol., 9, 639-45 (2008)
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J Wozniak, J Biederman, E Mick, J Waxmonsky, L Hantsoo, C.A Best, JE Cluette-Brown,and M Laposata. Omega-3 fatty acid monotherapy for pediatric bipolar disorder: A prospective open label trial. European Neuropsychopharmacology., 17 (6-7): 440-7 (2007)
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CA Best, T Sarkola, CJP Eriksson, JE Cluette-Brown and M Laposata. Increased plasma fatty acid ethyl ester levels following inhibition of oxidative metabolism of ethanol by 4-methylpyrazole treatment in human subjects. Alcoholism-Clinical and Experimental Research, 30(7):1126-1131 (2006)
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G. Popescu, T. Ikeda, K. Goda, C. A. Best-Popescu, M. Laposata, S. Manley, R. R. Dasari, K. Badizadegan and M. S. Feld, Optical measurement of cell membrane tension, Phys. Rev. Lett., 97, 218101 (2006)
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DM Yoerger, CA Best, BM McQuillan, GE Supple, JL Guererro, JE Cluette-Brown, A Hasaba, MH Picard, JR Stone and M Laposata. Rapid fatty acid ethyl ester synthesis by porcine myocardium upon ethanol infusion into the left anterior descending coronary artery. American Journal of Pathology, 168(5):1435-1442 (2006)
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CA Best, M Laposata, VG Proios and ZM Szczepiorkowski. Method to assess fatty acid ethyl ester binding to albumin. Alcohol and Alcoholism, 41(3):240-246 (2006).
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G. Popescu, T. Ikeda, C. A. Best, K. Badizadegan, R. R. Dasari and M. S. Feld, Erythrocyte structure and dynamics quantified by Hilbert phase microscopy, J. Biomed. Opt. Lett., 10, 060503 (2005)
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CA Best, JE, Cluette-Brown M Teruya, A Teruya and M Laposata. Red blood cell fatty acid ethyl esters: a significant component of fatty acid ethyl esters in the blood. J Lipid Res, 44(3):612-20 (2003)
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CA Best and M Laposata. Fatty acid ethyl esters: toxic non-oxidative metabolites of ethanol and markers of ethanol intake. Front Biosci, 8:e202-17 (2003)
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BL Soderberg, RO Salem, CA Best, JE Cluette-Brown, and M Laposata. Fatty acid ethyl esters: Ethanol metabolites that reflect ethanol intake, Am J Clin Pathol, 119 Suppl: s94-9 (2003)
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M Laposata, A Hasaba, CA Best, DM Yoerger, BM Mcquillan, RO Salem, MA Refaai and BL Soderberg, Fatty acid ethyl esters: recent observations, Prostaglandins Leukot Essent Fatty Acids, 67: 193-6 (2002)